diff --git a/src/djlint/helpers.py b/src/djlint/helpers.py
index 5cb7921..4ac11c2 100644
--- a/src/djlint/helpers.py
+++ b/src/djlint/helpers.py
@@ -12,7 +12,11 @@ def is_ignored_block_opening(config: Config, item: str) -> bool:
     """
     last_index = 0
     inline = list(
-        re.finditer(config.ignored_blocks, item, flags=re.IGNORECASE | re.VERBOSE)
+        re.finditer(
+            config.ignored_blocks,
+            item,
+            flags=re.IGNORECASE | re.VERBOSE | re.MULTILINE | re.DOTALL,
+        )
     )
 
     if inline:
@@ -64,7 +68,7 @@ def is_safe_closing_tag(config: Config, item: str) -> bool:
         re.finditer(
             re.compile(
                 config.ignored_inline_blocks + r" | " + config.ignored_blocks,
-                flags=re.IGNORECASE | re.VERBOSE,
+                flags=re.IGNORECASE | re.VERBOSE | re.MULTILINE | re.DOTALL,
             ),
             item,
         )
@@ -88,7 +92,8 @@ def inside_ignored_block(config: Config, html: str, match: re.Match) -> bool:
         for ignored_match in list(
             re.finditer(
                 re.compile(
-                    config.ignored_blocks, re.DOTALL | re.IGNORECASE | re.VERBOSE
+                    config.ignored_blocks,
+                    re.DOTALL | re.IGNORECASE | re.VERBOSE | re.MULTILINE | re.DOTALL,
                 ),
                 html,
             )
diff --git a/src/djlint/reformat.py b/src/djlint/reformat.py
index 44d8d3f..3dcab56 100644
--- a/src/djlint/reformat.py
+++ b/src/djlint/reformat.py
@@ -18,8 +18,11 @@ def reformat_file(config: Config, this_file: Path) -> dict:
     rawcode = this_file.read_text(encoding="utf8")
 
     compressed = compress_html(rawcode, config)
+
     expanded = expand_html(compressed, config)
+
     condensed = condense_html(expanded, config)
+
     indented = indent_html(condensed, config)
 
     beautified_code = indented
diff --git a/src/djlint/settings.py b/src/djlint/settings.py
index 328c5ed..2ca99a0 100644
--- a/src/djlint/settings.py
+++ b/src/djlint/settings.py
@@ -341,7 +341,8 @@ class Config:
             | <\?php
             | <script
             | <!--
-            | [^\{]{\#
+            | [^\{]{\#(?!\s*djlint\:\s*on)
+            | ^{\#(?!\s*djlint\:\s*on)
             | <pre
             | <textarea
             | {%[ ]*?blocktrans(?:late)?[^(?:%})]*?%}
@@ -568,7 +569,7 @@ class Config:
             | {\#\s*djlint\:\s*off\s*\#}.*?(?={\#\s*djlint\:\s*on\s*\#})
             | {%\s*comment\s*%\}\s*djlint\:off\s*\{%\s*endcomment\s*%\}.*?(?={%\s*comment\s*%\}\s*djlint\:on\s*\{%\s*endcomment\s*%\})
             # inline jinja comments
-            # | {\#(?!\s*djlint\:\s*(?:off|on)).*?\#}
+            | {\#(?!\s*djlint\:\s*(?:off|on)).*?\#}
             # handlebars
             | {{!--\s*djlint\:off\s*--}}.*?(?={{!--\s*djlint\:on\s*--}})
             # golang
diff --git a/tests/test_twig/__init__.py b/tests/test_twig/__init__.py
new file mode 100644
index 0000000..e69de29
diff --git a/tests/test_twig/test_comments.py b/tests/test_twig/test_comments.py
new file mode 100644
index 0000000..a3100fd
--- /dev/null
+++ b/tests/test_twig/test_comments.py
@@ -0,0 +1,32 @@
+"""Djlint tests specific to twig.
+
+run::
+
+   pytest tests/test_twig/test_comments.py --cov=src/djlint --cov-branch \
+          --cov-report xml:coverage.xml --cov-report term-missing
+
+   pytest tests/test_twig/test_comments.py::test_nested --cov=src/djlint --cov-branch \
+          --cov-report xml:coverage.xml --cov-report term-missing
+
+"""
+# pylint: disable=C0116
+
+from typing import TextIO
+
+from click.testing import CliRunner
+
+from tests.conftest import reformat
+
+
+def test_macro(runner: CliRunner, tmp_file: TextIO) -> None:
+    output = reformat(
+        tmp_file,
+        runner,
+        b"""{% if %}
+    {#
+        line
+    #}
+{% endif %}
+""",
+    )
+    assert output.exit_code == 0